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Incretins have been studied for more than 140 years, but advancements in the 2010s and 2020s highlight two: GIP (glucose-dependent insulinotropic polypeptide), from the upper gut, and GLP-1 (glucagon-like peptide-1), from the lower gut

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Professor Deanfield said: These findings have important clinical implications

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For type 2 diabetes mellitus with neurological complications , the UK uses a dual-coding approach following daggerasterisk conventions: Primary (underlying cause) code: E11.4 Type 2 diabetes mellitus with neurological complications This dagger code () must be paired with an appropriate asterisk code (*) from Chapter VI (Diseases of the nervous system) to specify the manifestation: G63.2 * Diabetic polyneuropathy (for distal symmetric polyneuropathy) G99.0 * Autonomic neuropathy in endocrine and metabolic diseases (for diabetic autonomic neuropathy) G59.0 * Diabetic mononeuropathy (for focal nerve involvement) Accurate code selection requires clinical documentation that clearly establishes the causal relationship between diabetes and neuropathy