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There seem to be multiple mechanisms for interleukins to stimulate ACTH release, but most of the acute effects of these agents are almost certainly via the hypothalamus (144)

10.1128/AAC.48.8.3112-3118.2004

Characteristics of the Aging Skin

We found that serum vitamin B 12 levels were significantly higher in cirrhotic patients with Child-Pugh C than in patients with chronic hepatitis or Child-Pugh A/B cirrhosis