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Pathway analysis According to the metabolite set enrichment analysis of KOA and control SF samples, tryptophan metabolism, betaine metabolism, glutamate metabolism, cysteine metabolism, glycine and serine metabolism, glutathione metabolism, pantothenate and CoA biosynthesis, taurine and hypotaurine metabolism, methionine metabolism, and homocysteine degradation were the most disturbed pathways (Fig

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Int J Epidemiol 2016;45:1987-96