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Efficacy and safety of dipeptidyl peptidase-4 inhibitor, sitagliptin, compared with the sufonylurea, glipizide, in patients with type 2 diabetes inadequately controlled on metformin alone: a randomized, double-blind, non-inferiority trial

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Hoffmann J, Jensen HE, Christiansen J, Olesen A, Loud FB, Hauch O

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Healthcare professionals emphasise that any consideration of combination treatment would require: Participation in a formal clinical trial with ethical approval Close monitoring by specialist physicians experienced in obesity medicine Regular assessment of cardiovascular, metabolic, and psychological parameters Informed consent regarding unknown risks Patients should be aware that reputable healthcare providers will not prescribe unlicensed combinations of weight loss medications

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