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Retatrutide is a triple agonist that targets GLP-1, GIP and glucagon receptors, giving it the broadest receptor profile currently under investigation among incretin peptides

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These medications carry a Black Box Warning for the potential risk of thyroid tumors

Based on current studies, arginine deprivation further compromises T cell function by reducing mTORC1 activity, leading to an increased proportion of memory-like T cells while diminishing effector functions and immune surveillance (92)