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For women in the menopause transition, this is more than a home repair issue

Tingling and Carpal Tunnel-Like Symptoms GH-induced fluid retention can compress peripheral nerves, causing tingling or numbness in the hands, often noticed upon waking

When astrocytes take up glutamate, not only is there post-synaptic attenuation of nearby neurons, but within the astrocyte there is a switch from oxidative metabolism to aerobic glycolysis, and glucose is diverted from the TCA cycle to glycolysis and greater lactate production

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It's not just medical conditions, though

Semin Cancer Biol (2020) 60:35161