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21 Given this critical findings, The ADA advises using GLP-1 RAs to treat type 2 diabetes in adults with MASH, citing histological benefits demonstrated in the mentioned phase 2 randomized controlled trials

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Notably, in a recent umbrella review of 14 meta-analyses, assessing pro/synbiotics on weight changes, most studies revealed a decrease in BMI and/or weight, favoring pro/synbiotics compared with placebo (26)