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This occurs through an in-frame fusion of the EWS gene at 22q12 and the FLI1 gene at 11q24 resulting in the formation of the EWS-FLI1 fusion gene product ( EWS/FLI-1 fusion gene are characterized by small round cells that are arranged closely to form a Homer-Wright daisy-chain structure and the membrane-positive staining for the MIC gene product, CD99, in 90% of the cases

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