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Novo in October 2024 took the extra step of arguing to the FDA that semaglutide is too complex to compound, asking the regulator to include the drug in its Demonstrable Difficulties for Compounding (DDC) listin turn keeping it out of reach for compounders even in times of shortage

Very provocative finding

Can Res 55:47714775 Mulcahy RT, Gipp JJ (1995) Identification of a putative antioxidant response element in the 5'-flanking region of the human gamma-glutamylcysteine synthetase heavy subunit gene

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4,5 US poison centers have reported a 1500% increase in calls related to semaglutide, highlighting the need for enhanced pharmacovigilance including for online sourcing harms

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