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This disorder is associated with mitochondrial abnormalities of respiratory function, Ca 2+ cycling, ROS/RNS production, mPTP opening, activation of different mechanisms of programmed cell death, disbalance of the processes of mitochondrial fusion, fission, and autophagy, and disturbances in synaptogenesis and synaptic transmission which affect the brain development and cause behavioral deficits
Cells were incubated in a humidity-controlled incubator at 37 C with 5% CO 2
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Hyperosmolar hyperglycaemic state (HHS) is a more relevant concern for people with type 2 diabetes experiencing severe hyperglycaemia
