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Cold Spring Harb Perspect Biol 10.1101/cshperspect.a040592 [DOI] [PMC free article] [PubMed] [Google Scholar] *.Chandel NS

[DOI] [PubMed] [Google Scholar] 96.Marenah L., Mcclean S., Flatt P.R., Orr D.F., Shaw C., Abdel-wahab Y.H.A

To achieve fat loss, you must maintain a caloric deficit

This new paradigm began with the discovery of leptin, by Jeff Friedman and others in 1994, the first hormone whose primary function is the regulation of body weight, by signaling from the adipose tissue to pro-opiomelanocortin (POMC) neurons [6] in the hypothalamus to reduce food intake