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*The AMPK pathway acts like your bodys energy sensor helping regulate how it uses and stores fat and sugar

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About the Study The researchers conducted a systematic review and meta-analysis according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines, and the study protocol was registered in the International Prospective Register of Systematic Reviews (PROSPERO) prior to data collection

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10.1155/2014/360438 8 BartmanS.CoppotelliG.RossJ

Cardiovascular outcomes trial : A separate long-term study required for FDA approval given the class's cardiovascular implications