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Weight loss outcomes vary by agent and dose: high-dose semaglutide (2.4mg/Wegovy) has shown mean weight reductions of approximately 15% in the STEP clinical trials, while liraglutide (3mg/Saxenda) typically achieves 5-8% weight loss

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New England Journal of Medicine , 389(6), 514526

Protective Effect of Estrogen As noted above, research suggests that estrogen may improve esophageal resistance to refluxed stomach fluids

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