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some individuals have genetic variants that reduce receptor binding or peptide pathway efficiency

Patient selection criteria include: Clear therapeutic indication : Tirzepatide should be prescribed for FDA-approved indications (type 2 diabetes or obesity with BMI 30 or 27 with weight-related comorbidity)

Cardiovasc Diabetol 18(1):138

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The treatment duration ranged from 40 days to 12 weeks, and daily doses of ALC varied from 13 g/day