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In the early years of migraine research, scientists believed that the headache portion of a migraine resulted from the dilation of blood vessels, while the aura portion of migraine was caused by vasoconstriction (Cutrer 2012)

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Animal studies Breeding and Housing Female C57BL/6 NTac mice (Taconic Bioscience, Lille Skensved, Denmark) and adipose-tissue specific human vaspin-transgenic mice on the C57BL/6N background (VasTg, described in ref

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Skipping days or using it sporadically could reduce its effectiveness