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Because angiogenesis is a defining hallmark of tumor growth and metastatic progression, any therapeutic agent that enhances neovascularization could, in theory, facilitate tumor expansion and promote metastatic dissemination

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GHK-Cu is chemically incompatible with L-ascorbic acid (vitamin C) in the same formulation the acidic pH required to stabilize vitamin C (pH 2.53.5) causes immediate dissociation of the copper chelate complex, destroying the peptides bioactivity

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