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This metabolic keto-adaptation or shift in fuel sourcing can leave you feeling drained while your mitochondria and cells adjust to the new environment

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This creates a reinforcing cycle

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Annu Rev Pharmacol Toxicol 45:5188 Hirrlinger J, Dringen R (2005) Multidrug resistance protein 1-mediated export of glutathione and glutathione disulfide from brain astrocytes