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Western blots showed decreased expression of enzymes of GSH synthesis (catalytic subunit of glutamate cysteine ligase [GCLC], modifier subunit of GCL [GCLM], and glutathione synthetase [GSS]) indicating impaired GSH synthesis as a cause for GSH deficiency

This is to a different degree due to their mechanism of modification of the metabolic syndrome (Figure 6), the cellular sensitization of insulin, and the effect of insulin itself on tissues