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Office of Dietary Supplements, US National Institutes of Health
PMID 18709880
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Studies comparing localized versus systemic delivery for other biologics (botulinum toxin, platelet-rich plasma) suggest systemic routes produce more uniform results across larger treatment areas
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In vitro studies confirm minimal cytotoxicity with no impact on cell viability up to 100 M concentrations across multiple cell types, though higher concentrations may produce non-specific effects that could confound experimental results
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