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Adverse reactions and tolerability: Since they are administered via injection and affect gastric emptying (particularly in the case of shorter-acting agents), GLP-1 receptor agonists present some tolerability concerns

dose of IV carnitine Loading dose 100 mg/kg IV over 30 minutes (maximal dose of 6 grams)

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These results demonstrate that tirzepatide is associated with a higher percentage of patients achieving significant, clinically meaningful weight loss thresholds compared to semaglutide