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Other indications include malabsorption disorders (such as Crohn's disease or coeliac disease), following gastric surgery, strict vegan diets without supplementation, and certain medications that interfere with B12 absorption

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Clinical distinction between medication-induced effects and weight-loss-associated changes remains challenging

There is an urgent need for a comprehensive review of the mechanisms of the BBB impairment, especially when considering the trio of crucial aspects in the context of various neurodegenerative conditions

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