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The original fibroblast collagen-synthesis work reported stimulation beginning between 10 -12 and 10 -11 M and peaking at 10 -9 M that is, one nanomolar

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The toxin MPP + can affect TCA by inhibiting mitochondrial KGDHC in PD animal models

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doi: 10.1038/s41556-024-01360-8 65

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