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COA / Lab results Evidence: Clinical trial Pros Triple GLP-1 / GIP / glucagon agonism in one peptide raises energy expenditure, not appetite alone Largest weight reduction reported for an incretin-class compound (~24% at 12 mg, 48-wk phase 2) Reductions in HbA1c, visceral fat and liver-fat content across trials Once-weekly subcutaneous dosing (albumin-bound half-life) Cons GI effects require gradual multi-week dose titration Newest of the GLP-1 class phase 3 (TRIUMPH) topline only

By using significantly lower doses than standard therapy, some individuals tolerate GLP-1 activation with reduced pancreatic stress

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Low TSH indicates high thyroid function, or hyperthyroidism

L-ascorbic acid is a trustworthy source of vitamin C because its thoroughly researched

95% CI, 0.87-0.97) compared with women who did not receive a prescription