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Escalation of Care: if individual glycemic (blood sugar targets are not reached with first-line therapies, the guide suggests adding: DPP-4 inhibitors Sulfonylureas Pioglitazone Insulin-based treatments

Regul Pept 53: 47-59, 1994

PTEN antagonises Tcl1/hnRNPK-mediated G6PD pre-mRNA splicing which contributes to hepatocarcinogenesis

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benefits from these drugs also include treatment of other satellite symptoms, such as depression, sleep disturbances, and irritable bowel disease