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These steps are not required, but they help strengthen long-term results

Achieving therapeutic concentrations in the retina via systemic routes may require doses high enough to increase the risk of extraocular adverse effects [128]

They found that this effect was mediated through a complex inter-organ crosstalk involving the gut-brain-liver axis

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A zinc-binding motif engineered into the intein enhances pH sensitivity and suppresses premature cleavage

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