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doi: 10.1016/j.ajpath.2012.09.016 194 LeeFTCaoZLongDMPanagiotopoulosSJerumsGCooperMEet al

Candida produces acetaldehyde, which is structurally similar to formaldehyde and is highly neurotoxic: it depletes glutathione (the brains primary antioxidant), impairs dopamine metabolism, and damages mitochondria in neural tissue

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The drug increases risk of acute angle-closure glaucoma, metabolic acidosis, and cognitive impairmentside effects that can worsen when combined with semaglutide's gastrointestinal stress on electrolyte balance and hydration status