eBioMedicine, 107 , 105284
[DOI] [PMC free article] [PubMed] [Google Scholar] 50.Merlin J.P.J., Mathavarajah S., Dellaire G., Murphy K.P.J., Rupasinghe H.P.V
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These findings were further corroborated by Western blot analysis, in which we observed increased -H2AX expression, decreased pNPM1 (T199) protein levels and increased expression of autophagosome LC3A/B proteins (Fig
Why Long-Term Risks Are Still Uncertain GLP-1 drugs are relatively new, and large-scale studies have primarily focused on: 612 month use diabetes-specific outcomes cardiovascular risk reduction What we dont have yet: long-term (515 year) safety data long-term pancreatic outcome studies long-term GI motility tracking full population data on chronic or permanent side effects long-term cancer risk data Large numbers of patients now take GLP-1 drugs indefinitely , especially for weight loss
Clinical Factors That Shape Provider Recommendations for Nursing Parents Healthcare providers evaluating GLP-1 use in lactating patients weigh multiple factors: breastfeeding duration planned, maternal metabolic urgency, available alternatives, and infant monitoring feasibility