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BMC Genomics, 10 (Article #375) 375, 1-8

Diurnal changes in tomato glutathione transferase activity and expression

Baltruskeviciene, E

This accumulation promotes Parkin recruitment and activates its E3 ubiquitin ligase activity, resulting in the ubiquitination of damaged mitochondria and the initiation of autophagic degradation

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Hence, the disturbance of the circadian clock leads to a number of cellular misregulations, including the downregulation of immune responses (Grundy et al., Circadian Clock Associated 1 ( CCA1 ) (Lai et al., 2012)