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So, due to the greater increase in brain pyruvate levels with aging, the malate/pyruvate decreased substantially after 15 months of age, reflecting an oxidative shift of the cytoplasmic [NADPH]/[NADP + ] with age (Ding et al., 2021), again opposite to the results obtained using C57BL/6J mice (Dong and Brewer, 2019)
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Virtual-reality-based cognitive behavioural therapy versus waiting list control for paranoid ideation and social avoidance in patients with psychotic disorders: a single-blind randomised controlled trial
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Artificial intelligence in ophthalmology: accuracy, challenges, and clinical application
