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FOXO4-DRI is a modified version of this interaction domain, designed to disrupt the FOXO4-p53 binding

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Unknown Long-Term Safety Profile: A short plasma half-life of under 30 minutes in rats and dogs, alongside low bioavailability after intramuscular administration, raises critical questions about what occurs with higher, repeated, or long-term exposures in humans

Several features of ferroptosis, such as iron accumulation, 614,615 glutathione depletion, 616 and lipid peroxidation, 617,618 are also found in HD patients and animal models, suggesting that ferroptosis may be involved in the regulation of HD pathogenesis