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At 96 weeks, Vijiaratnam and colleagues reported that MDS-UPDRS III off-medication scores increased by a mean of 5.7 points in the exenatide group and 4.5 points in the placebo group

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220,258,259 While the efficacy of statins in alleviating DPN symptoms remains unclear, 260,261 emerging lipid-lowering therapies showed potential in improving nerve function in DPN models

Furthermore, IL-22-induced claudin-2 upregulation can drive diarrhea and pathogen clearance [90]

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