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The obtained active site model was further substantiated as amino acid residues Arg 166 , Arg 284 and Ser 447 were located at an appropriate distance for hydrogen bonding interaction with the carboxylate group of the substrate

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Table 12 Composition of co-formulation 13, co-formulation 14, and co-formulation 15 1 MS: molar substitution, corresponds to hydroxy propyls per glucose unit Preparation process Formulations were prepared as described in example 1

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