(5) Adverse effects and management: Cholinergic muscarinic effects such as diarrhea, abdominal cramping, and increased salivation are common and may be managed with agents such as propantheline or loperamide
Dekhuijzen PN, van Beurden WJ
Science Advances , 11 (15), eads3506 Seo, W., Jung, B., Roh, T., Shin, H
Intercurrent illnesses or medication changes (including addition of sedating medications or unavailability of regular symptomatic AD medications): This estimand will be analysed in participants who undergo follow-up RBANS assessment at 180 days (+0, 10 days) and who have taken at least 80% of the study medication, and where there have been no intercurrent events blindly adjudicated as affecting cognition (principal stratum strategy) Secondary estimand epigenetic change 1
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