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found that LPS stimulation led to an approximately 30-fold accumulation of succinate in mouse bone marrow-derived macrophages (BMDMs), which in turn specifically promoted the transcription and expression of IL-1 by inhibiting prolyl hydroxylase (PHD) and stabilizing HIF-1 ( During macrophage metabolic reprogramming, amino acid metabolism does not operate independently, but is embedded within the overall metabolic network

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Patients with uncontrolled diabetes, active cancer, or significant cardiovascular disease typically require careful assessment before peptide initiation

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Doppler examination did not detect any shunt signal at the systolic ventricular level

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J Exp Bot 53(372):12831304

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Early clinical studies with liraglutide

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