When a growing number of people began suing Novo Nordisk and Eli Lilly over their weight-loss and diabetes drugs, a panel of judges decided the cases were similar enough to be consolidated in front of one judge
Blood sugar regulation has been consistent for months
Important considerations include: Tirzepatide is not indicated for type 1 diabetes or diabetic ketoacidosis and is not a substitute for insulin No dose adjustment is required in renal impairment, but patients should be monitored for dehydration risk, particularly with significant gastrointestinal side effects Caution is advised in patients with a history of pancreatitis Warnings and precautions apply for patients with personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2 Prescribing in primary care requires initiation at 2.5 mg once weekly for 4 weeks (a non-therapeutic starting dose to improve tolerability), then escalation to 5 mg weekly
Queiroz MAF, Neves P, Lima SS, Lopes JDC, Torres M, Vallinoto I, et al
Insulin-like growth factor has a greater role in growth than insulin but both are essential for glucose regulation
They work by mimicking a hormone naturally produced in the gut called glucagon-like peptide-1 (GLP-1), but with a longer-lasting effect
