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Recent studies have explored brain capillary damage as a potential biomarker for cognitive dysfunction [284]

Wagle SR, Kovacevic B, Ionescu CM, Foster T, Lim P, Brunet A, McLenachan S, Carvalho L, Mikov M, Mooranian A

It has been shown that VPA therapeutic metabolites are able to induce the Akt/mTOR/p70S6K pathway through the induction of phosphatidylinositol-3-OH kinase, which leads to a decrease in collagen content and fibrosis in skeletal muscles, a decrease in hind limb contractures, an increase in the integrity of the myocyte sarcolemma, a decrease in the number CD8-positive inflammatory cells, and an increase in the level of activated Akt in the skeletal muscles of experimental animals [13]

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