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Under the challenge of hypobaric hypoxia induced by long-term high-altitude exposure, abnormalities in the gut microbiota and microbial metabolites can lead to high-altitude heart disease and high-altitude polycythemia in rats, primarily driven by bacterial families such as Prevotellaceae, Porphyromonadaceae , and Streptococcaceae (Pan et al., 2022)
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337 The choice of hypoglycemic agents for initial monotherapy should be personalized considering the need to reduce MDS-related TOD, such as weight management and comorbidities, as demonstrated above
ESRRA (estrogen-related receptor ) is a key coordinator of transcriptional and post-translational activation of autophagy to promote innate host defense
