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[3] The details of drug distribution, metabolism and excretion remain unclear (as of 2026), but since it is a small peptide with a short half-life, it is expected that it is quickly broken down into shorter peptide fragments and amino acids

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Furthermore, age-related changes in gut microbiota favor microbiologic species that induce higher production of TMAO, correlating with the increase in endothelial dysfunction, subsequent atherosclerosis, and CVD associated with aging [61, 62, 64, 67]

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