can you become resistant to glp 1 As a pharmacist, one of my biggest concerns with long-term GLP-1 use is how little ongoing monitoring many people receive after starting these medications. Appetite suppression and rapid weight loss sometimes Why GLP-1 Plus LDN Wins

Xu X, Pang Y, Fan X

The basic formula Concentration (mg/mL) = Total peptide (mg) Water volume (mL) For a 70mg vial with 3mL water: 70 3 = 23.33 mg/mL Volume to draw (mL) = Desired dose (mg) Concentration (mg/mL) For 2.33mg dose at 23.33 mg/mL: 2.33 23.33 = 0.10mL = 10 units on an insulin syringe Common vial sizes and calculations 42mg vial with 1.8mL water: Concentration: 23.33 mg/mL Standard dose (2.33mg): 10 units Conservative dose (1.165mg): 5 units Vial provides approximately 18 doses at standard protocol 70mg vial with 3mL water: Concentration: 23.33 mg/mL Standard dose (2.33mg): 10 units Conservative dose (1.165mg): 5 units Vial provides approximately 30 doses at standard protocol 70mg vial with 2mL water (higher concentration): Concentration: 35 mg/mL Standard dose (2.33mg): 6.7 units (round to 7) Conservative dose (1.165mg): 3.3 units (round to 3) Smaller volumes make precise measurement more difficult The SeekPeptides peptide calculator automates these calculations for any vial size and desired dose

The standard dilution: dissolve standard with 1 mL of distilled water (4) to a concentration of 10 mg/mL

Coto V, D'Alessandro L, Grattarola G, and et al

In gastric L-cells, the bioactive forms of GLP-1, GLP 737 (glycine-extended GLP-1), and GLP 737 amide , are cleaved from its precursor (pre)proglucagon by prohormone convertase (PC)1 and PC3, which co-generates GLP-2 and oxyntomodulin

At the same time, fertility and pregnancy considerations demand thoughtful counseling when prescribing GLP-1 agents