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Polletta L, Vernucci E, Carnevale I, Arcangeli T, Rotili D, Palmerio S, Steegborn C, Nowak T, Schutkowski M, Pellegrini L, Sansone L, Villanova L, Runci A, Pucci B, Morgante E, Fini M, Mai A, Russo MA, Tafani M

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[6] A second study by Ionescu and Frohman gave a single injection to healthy men and showed that GH secretion rose driven mostly by a marked increase in trough GH while preserving the normal pulsatile pattern, with a corresponding rise in IGF-1

These findings suggest that a large dose of creatine could mitigate some of the harmful effects of sleep deprivation on the brain and cognitive function

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