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These include the regulation of inflammation, promotion of cell migration and fibroblast proliferation, stimulation of collagen synthesis, enhancement of angiogenesis, and remodeling of the ECM 24 , 32 - 36 , 58 - 60

Free copper can undergo redox cycling, leading to the formation of ROS, including hydroxyl radicals (HO) via Fenton and Harber-Weiss reactions [13, 17]

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Microscopically, transmural hyperemia of the gastrointestinal tract, intestinal mucosa villi reduction, crypt reduction with focal denudation of superficial epithelia, and large bowel dilatation were all inhibited

Shirani MP, Rezaei B, Khayamian T, Dinari M, Shamili FH, Ramezani M, et al