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Among participants with study-defined prediabetes, body weight reduction explained 52% (95% confidence interval [30.3, 87.8]) of the estimated treatment difference in HOMA2-IR observed at Week 72 (Table S2)

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When I did my weekly jab just now, (a) the needle pricked quite hard which it hasn't ever done before, and (b) it felt a bit hard to push the plunger in but it's a new pen so I just thought it might be slightly different and I disregarded it and just pushed it all the way in anyway