doi:10.1093/nutrit/nuu011
Mounjaro combines glucose-dependent insulinotropic polypeptide signaling with GLP1 receptor activity, which often yields faster and larger weight loss in trials
These include: Nausea (the most common complaint, particularly during dose escalation) Vomiting Diarrhoea Constipation Decreased appetite These effects are generally dose-dependent and tend to be most pronounced during the initial weeks of treatment or following a dose increase
The incidence typically decreases over time as the body adapts to the medication, with many patients reporting improvement after several weeks at a stable dose
Key hormonal changes associated with weight loss include: Decreased leptin signalling to the hypothalamus Reduced oestrogen production from adipose tissue Alterations in insulin sensitivity and androgen levels These metabolic and hormonal adaptations are the body's way of conserving energy during perceived scarcity, but they can temporarily disrupt normal reproductive function
Kwak SH, Choi SH, Jung HS, Cho YM, Lim S, Cho NH, et al
