4.25 mg tirzepatide (Zepbound, Mounjaro): Weight Loss, Diabetes, Dosage & Side Effects Tirzepatide Oral | Starts at

Your doc might need to switch things up

Deficiencies in vitamin B12 (particularly in patients also taking metformin), iron, and other nutrients have been linked to cognitive symptoms

doi: 10.1152/physrev.00015.2019 111 GrossP

Confidence improves

The science: During perceived energy scarcity, the body engages peripheral vasoconstriction reducing blood flow to hands, feet, and skin surface to preserve heat for vital organs GLP-1 and GIP receptor activation may impact circulatory function, though research is limited Low blood sugar (see mechanism #6) can trigger vasoconstriction Additional factors: Rapid weight loss can temporarily affect blood pressure regulation Dehydration (common on these peptides) reduces blood volume and affects circulation Potential for mild anemia if nutrition isnt adequatehemoglobin carries oxygen needed for heat production Why you feel cold: Less blood flow to extremities = cold hands and feet, even when your core temperature is normal

- Results can be observed as quickly as within a few weeks, but optimal results usually require consistent administration alongside proper diet and exercise over months