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SGLT2 inhibitors enhance fatty acid oxidation and ketogenesis, potentially reducing renal accumulation of long-chain acylcarnitines [172], while metformin attenuates the acute eGFR decline induced by SGLT2 inhibitors [173]
Funding This work was supported by Cancer Research UK (PRCRPG-Nov21\100002)
Julie Stewart is a writer and content strategist whose work has also appeared in Health, and Womens Health, Everyday Health, Vice, and Shape.
The systemic toxicity of microtubule-disrupting agents are likely due to non-specific uptake by normal cells and premature delivery, so advances in conjugation technology to prevent non-specific endocytosis and payload release may help overcome these challenges 24
The latter events induce glycogenolysis and gluconeogenesis, both of which are hyperglycemia-inducing and which thus, counter insulins effect on blood glucose levels