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Potential theoretical concerns include: Unregulated angiogenesis Immune system modulation Tumor growth acceleration under certain conditions Reproductive safety implications Cardiovascular remodeling There is no clinical evidence demonstrating these risks in humans, but comprehensive trials evaluating these endpoints do not exist

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3 Hepatocyte necrosis: apoptosis-inducing factor (AIF) and endonuclease G, along with other mitochondrial components, are released into the cytoplasm, causing chromatin condensation and DNA fragmentation

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