In high-risk patients, use semaglutide with caution
Both medications affect similar hormone pathways that control appetite, digestion, and blood sugar
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According to the American Diabetes Association's Standards of Care, GLP-1 RAs with proven cardiovascular benefit, such as semaglutide, may be considered as first-line therapy in patients with type 2 diabetes who have established atherosclerotic cardiovascular disease or high cardiovascular risk, independent of metformin use
The constipation rate in particular (24.2%) is something to be aware of if you have IBS-C
Combining phentermine and tirzepatide may amplify certain adverse effects and introduce unique safety concerns that require careful clinical monitoring
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