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10.1016/j.ejphar.2007.05.072 141 TonoliniM.MagistrelliP

In summary, a diverse array of natural products demonstrates potent immunomodulatory effects in PH models, primarily by dampening the activation of innate immune cells, including macrophages and neutrophils, restoring the balance of adaptive immunity such as the Treg/Th17 axis, and disrupting pro-inflammatory cytokine networks, specifically NF-B and NLRP3

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Across all trials, participants were stratified into peptide-exposed cohorts and placebo control groups

In the early 2000s, excitement about Epitalon increased, even more, when scientists found it could activate telomerase, leading to the regrowth of telomeres