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PCa incidence per 10,000 patient-years in cohorts 1 and 2 was 54.4 and 30.7, respectively, which is lower than 116 reported by the PLCO (Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial) and 96.6 reported by the ERSPC ( European Randomized Study of Screening for Prostate Cancer)

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1986 Aug;122(8):896-9

Excessive mitochondrial fission in tumor cells triggers oxidative stress, leading to a sharp increase in reactive oxygen species (ROS), which in turn promotes lipid peroxidation and facilitates ferroptosis [55]