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By contrast, the GH group increased in lean body mass (1.13 +/- 1.04 kg) and had a positive nitrogen balance (1.81 +/- 2.06 g/day) (This link describes the mechanism through which this happens) Increased Lean Muscle Mass Pooled results of 11 RCTs showed that GH administration significantly increases the lean body mass, total water content, and extracellular water and reduces the fat mass (0.67, 95% CI: 0.93